Scientific research pioneered at Harvard in 2012 showed placebos can help even when you're in on the secret.
Placebos without deception.
Open-label placebos (OLPs) are “dummy” medications that contain no active medicine, but unlike traditional placebos, the patient is told upfront they’re taking a placebo.
The process of undergoing inert treatment can trigger real mood and pain-relief neurological pathways, the very same ones activated by prescription medication.
A 2025 Harvard study showed a 79% reduction in PMS symptoms using Open Label Placebo.
"The results of our clinical trial indicate that OLP provided with a treatment rationale is an effective, safe, and acceptable treatment for PMS."
Decreased symptoms.
79%
Reported a clinically meaningful decrease in symptoms
Improved quality of life.
83%
Reported a decrease in life interference from PMS.
Consume your OLP treatment, guided daily by the app
2. Digital Behavioural Therapy
Follow the therapeutic exercise in the app to improve how you feel
3. Written Behavioural Therapy
Write out your exercise by hand to better process your thoughts and receive insight
Backed by Gold-Standard Science.
Hundreds of peer-reviewed studies from Ivy League labs to leading cancer centers have confirmed the positive effect of OLP across PMS, fatigue, mood, and gut disorders.
Rabkin J.G., McGrath P.J., Rabkin R. et al.
Open-Label Placebo for the Treatment of Unipolar Depression: Results from a Randomized Controlled Trial.
Open-Label Placebo for the Treatment of Cancer-Related Fatigue in Patients With Advanced Cancer: A Randomized Controlled Trial. Oncologist 27, 815-823 (2022).
The roles of expectation, comparator, administration route, and population in open-label placebo effects: a network meta-analysis. Sci Rep 13, 11827 (2023).
The four neurodynamic mechanisms that underly the effectiveness of our approach.
Conditioned Healing Reflex
A lifetime of pill-taking and healthcare has wired your nervous system to launch repairs the moment you engage with a bottle or therapeutic healthcare advice. Our protocol lights up the same neural circuits that real drugs and real healthcare practices activate.
New & Improved Expectations
Clear, scientific rationale about OLPs sets a new prediction in your brain: “I’m about to improve.” Your brain hunts for positive evidence to confirm this expectation and dampens your anxiety in the process.
Feedback Loop Reset
Your condition creates noisy feedback loops that amplify pain - you've received discomfort before so your brain expects it again. Our placebo protocol can interrupt your existing negative thought loops, giving your neural networks a chance to recalibrate.
The Reward of Agency
The very decision to try a Copables program and take your own health into your own hands can help. Neuroscience research shows that simply having the opportunity to make choices activates reward pathways in the brain, independent of whether those choices lead to better outcomes. The act of choosing treatment over helplessness itself feels good.
No meds. No huge bills. No doctor's office.
No chemicals. No side effects.
Less than a single therapy session.
Minutes a day in the comfort of home.
A proven method, powered by science and technology.
Copables blends Cognitive Behavioural Therapy (CBT) — the world’s leading evidence-based behavioral health approach — with guided daily writing and digital feedback. Each exercise helps re-train stress and symptom responses while amplifying the effects of your daily OLP ritual.
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